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Article

Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes.

Nature genetics - 1 Mar 2018

Han Longsen, Ren Chao, Li Ling, Li Xiaoyan, Ge Juan, Wang Haichao, Miao Yi-Liang, Guo Xuejiang, Moley Kelle H, Shu Wenjie, Wang Qiang

Abstract excerpt

Maternal obesity can impair embryo development and offspring health, yet the mechanisms responsible remain poorly understood. In a high-fat diet (HFD)-based female mouse model of obesity, we identified a marked reduction of Stella (also known as DPPA3 or PGC7) protein in oocytes. Starting with this clue, we found that the establishment of pronuclear epigenetic asymmetry in zygotes from obese mice was severely...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29459681
DOI: 10.1038/s41588-018-0055-6

Genes

DPPA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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