Association of Uterine Fibroids GWAS-Significant Loci rs11031731 THEM7P/WT1 and rs58415480 SYNE1 with the Risk of Obesity.

doi:10.1007/s10517-026-06689-8

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Association of Uterine Fibroids GWAS-Significant Loci rs11031731 THEM7P/WT1 and rs58415480 SYNE1 with the Risk of Obesity.

Bulletin of experimental biology and medicine - 1 Mar 2026

Gliantseva L A, Ragulina K I, Markina T V, Rukavitsyn V R, Lazareva G A, Denisyuk T A, Medvedeva I N, Bushueva O Yu

Abstract excerpt

Uterine fibroids and obesity are comorbid conditions with similar pathogenetic mechanisms. The aim of this study was to analyze the association of GWAS-significant uterine fibroid loci with the risk of obesity. DNA genotyping of 115 obese and 218 non-obese patients for 17 SNPs was performed by real-time PCR. An association was established between rs58415480 SYNE1 (effect G allele; OR = 0.61; p = 0.019) and...

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PMID: 42230488
DOI: 10.1007/s10517-026-06689-8

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