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Article

High-fat diet-induced and genetically inherited obesity differentially alters DNA methylation profile in the germline of adult male rats

19 Nov 2020

Abstract excerpt

BACKGROUND: Paternal obesity has been associated with reduced live birth rates. It could lead to inheritance of metabolic disturbances to the offspring through epigenetic mechanisms. However, obesity is a multifactorial disorder with genetic or environmental causes. Earlier we had demonstrated differential effects of high-fat diet-induced obesity (DIO) and genetically inherited obesity (GIO) on metabolic,...

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PMID: 33213487
DOI: 10.1186/s13148-020-00974-7

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