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Maternal Obesity Induces the Meiotic Defects and Epigenetic Alterations During Fetal Oocyte Development

13 Jun 2024

Abstract excerpt

It has been widely reported that obesity adversely impacts reproductive performance of females. However, the effects of maternal obesity on fetal germ cells remain poorly understood. In the present study, by employing a high-fat diet (HFD)-based mouse model, it is discovered that maternal obesity disrupts the chromosomal synapsis and homologous recombination during fetal oogenesis. Moreover, transcriptomic...

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PMID: 38868907
DOI: 10.1002/advs.202309184

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