Article
Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process.
Cell metabolism - 2 Mar 2021
Mimouni Nour El Houda, Paiva Isabel, Barbotin Anne-Laure, Timzoura Fatima Ezzahra, Plassard Damien, Le Gras Stephanie, Ternier Gaetan, Pigny Pascal, Catteau-Jonard Sophie, Simon Virginie, Prevot Vincent, Boutillier Anne-Laurence, Giacobini Paolo
Abstract excerpt
Polycystic ovary syndrome (PCOS) is the most common reproductive and metabolic disorder affecting women of reproductive age. PCOS has a strong heritable component, but its pathogenesis has been unclear. Here, we performed RNA sequencing and genome-wide DNA methylation profiling of ovarian tissue from control and third-generation PCOS-like mice. We found that DNA hypomethylation regulates key genes associated with...
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