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Article

DNA Methylation in Oocytes and Liver of Female Mice and Their Offspring: Effects of High-Fat-Diet–Induced Obesity

6 Dec 2013

Abstract excerpt

BACKGROUND: Maternal obesity has adverse effects on oocyte quality, embryo development, and the health of the offspring. OBJECTIVES: To understand the underlying mechanisms responsible for the negative effects of maternal obesity, we investigated the DNA methylation status of several imprinted genes and metabolism-related genes. METHODS: Using a high-fat-diet (HFD)-induced mouse model of obesity, we analyzed the...

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PMID: 24316659
DOI: 10.1289/ehp.1307047

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