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Single-cell RNA transcriptomics in mice reveals embryonic origin of fibrosis due to maternal obesity

31 Oct 2024

Abstract excerpt

BACKGROUND: Over 40% of pregnant women in the USA are obese which negatively affects fetal development and offspring health. Maternal obesity (MO) leads to fibrotic infiltration in multiple tissues and organs of offspring during their adulthood although the origin and mechanisms are unclear. METHODS: C57BL/6J female mice were fed a control and high-fat diet to mimic MO condition. Embryonic somatic tissues were...

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PMID: 39476533
DOI: 10.1016/j.ebiom.2024.105421

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