Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Non-cell-autonomous function of DR6 in Schwann cell proliferation.

The EMBO journal - 3 Apr 2018

Colombo Alessio, Hsia Hung-En, Wang Mengzhe, Kuhn Peer-Hendrik, Brill Monika S, Canevazzi Paolo, Feederle Regina, Taveggia Carla, Misgeld Thomas, Lichtenthaler Stefan F

Abstract excerpt

Death receptor 6 (DR6) is an orphan member of the TNF receptor superfamily and controls cell death and differentiation in a cell-autonomous manner in different cell types. Here, we report an additional non-cell-autonomous function for DR6 in the peripheral nervous system (PNS). DR6-knockout (DR6 KO) mice showed precocious myelination in the PNS Using an in vitro myelination assay, we demonstrate that neuronal DR6...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid Precursor Protein Secretases
Share to Cell Death

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hybridomas

Share to Metalloproteases

Share to Myelin Sheath

Share to Paracrine Communication

Share to Receptors, Tumor Necrosis Factor

Share to Schwann Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 29459438
DOI: 10.15252/embj.201797390
PMCID: PMC5881626

Genes

ADAM10
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non-cell-autonomous function of DR6 in Schwann cell proliferation.PMID 29459438Read ↗

dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.Semantic proximity Read ↗

TNFalpha mediates Schwann cell death by upregulating p75NTR expression without sustained activation of NFkappaB.Semantic proximity Read ↗

Pathologic and Therapeutic Schwann CellsSemantic proximity Read ↗

Transforming growth factor beta (TGFbeta) mediates Schwann cell death in vitro and in vivo: examination of c-Jun activation, interactions with survival signals, and the relationship of TGFbeta-mediated death to Schwann cell differentiation.Semantic proximity Read ↗

Sarm1 Gates the Transition from Protective to Repair Schwann Cell States Following Nerve InjurySemantic proximity Read ↗

Glial-derived prodegenerative signaling in the Drosophila neuromuscular system.Semantic proximity Read ↗

SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injurySemantic proximity Read ↗

Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom RevolutionSemantic proximity Read ↗

ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet mediated degenerationSemantic proximity Read ↗

Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system.Semantic proximity Read ↗

Activin receptors regulate the oligodendrocyte lineage in health and diseaseSemantic proximity Read ↗

New discovery rarely runs smooth: an update on progranulin/TNFR interactionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.