Article
Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system.
Nature neuroscience - 1 Dec 2009
Ohno Mikiko, Hiraoka Yoshinori, Matsuoka Tatsuhiko, Tomimoto Hidekazu, Takao Keizo, Miyakawa Tsuyoshi, Oshima Naoko, Kiyonari Hiroshi, Kimura Takeshi, Kita Toru, Nishi Eiichiro
Abstract excerpt
Axonal maturation and myelination are essential processes for establishing an efficient neuronal signaling network. We found that nardilysin (N-arginine dibasic convertase, also known as Nrd1 and NRDc), a metalloendopeptidase enhancer of protein ectodomain shedding, is a critical regulator of these processes. Nrd1-/- mice had smaller brains and a thin cerebral cortex, in which there were less myelinated fibers...
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