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Article

TNFalpha mediates Schwann cell death by upregulating p75NTR expression without sustained activation of NFkappaB.

Neurobiology of disease - 1 Nov 2005

Boyle Kristy, Azari Michael F, Cheema Surindar S, Petratos Steven

Abstract excerpt

Administration of tumour necrosis factor alpha (TNFalpha) to axotomised mouse neonatal sciatic nerves increased Schwann cell apoptosis in the distal nerve segments, 5-fold greater than axotomy alone. TNFalpha upregulated the low affinity neurotrophin receptor, p75NTR, indicative of phenotype reversion in Schwann cells. Furthermore, re-expression of p75NTR and downregulation of the pro-myelinating transcription...

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Source

Identifiers

PMID: 15905096
DOI: 10.1016/j.nbd.2005.03.022

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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