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New discovery rarely runs smooth: an update on progranulin/TNFR interactions

25 Sept 2015

Abstract excerpt

Progranulin (PGRN) is a growth factor implicated in various pathophysiological processes, including wound healing, inflammation, tumorigenesis, and neurodegeneration. It was previously reported that PGRN binds to tumor necrosis factor receptors (TNFR) and has therapeutic effects in inflammatory arthritis (Tang et. al, in Science 332:478-484, 2011); however, Chen et al. reported their inability to demonstrate the...

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PMID: 26408020
DOI: 10.1007/s13238-015-0213-x

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