Phenotypic heterogeneity of hereditary diffuse gastric cancer: report of a family with early-onset disease.

doi:10.1016/j.gie.2018.02.008

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Article

Phenotypic heterogeneity of hereditary diffuse gastric cancer: report of a family with early-onset disease.

Gastrointestinal endoscopy - 1 Jun 2018

Gullo Irene, Devezas Vitor, Baptista Manuela, Garrido Luzia, Castedo Sérgio, Morais Rui, Wen Xiaogang, Rios Elisabete, Pinheiro Jorge, Pinto-Ribeiro Inês, Ferreira Rui M, Preto John, Santos-Antunes João, Marques Margarida, Campos Miquel, Almeida Filipe, Espinheira Maria do Céu, Amil Dias Jorge, Figueiredo Céu, Oliveira Carla, Trindade Eunice, Carneiro Fátima

Abstract excerpt

BACKGROUND AND AIMS: The time course for the development of clinically significant hereditary diffuse gastric cancer (HDGC) is unpredictable. Little is known about the progression from preclinical, indolent lesions to widely invasive, aggressive phenotypes. Gastroendoscopy often fails to detect early lesions, and risk-reducing/prophylactic total gastrectomy (PTG) is the only curative approach. We present an HDGC...

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PMID: 29454568
DOI: 10.1016/j.gie.2018.02.008

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