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FOXL2 and TERT promoter mutation detection in circulating tumor DNA of adult granulosa cell tumors as biomarker for disease monitoring.

Gynecologic oncology - 1 Aug 2021

Groeneweg Jolijn W, Roze Joline F, Peters Edith D J, Sereno Ferdinando, Brink Anna G J, Paijens Sterre T, Nijman Hans W, van Meurs Hannah S, van Lonkhuijzen Luc R C W, Piek Jurgen M J, Lok Christianne A R, Monroe Glen R, van Haaften Gijs W, Zweemer Ronald P

Abstract excerpt

OBJECTIVE: Adult granulosa cell tumors (aGCTs) represent a rare, hormonally active subtype of ovarian cancer that has a tendency to relapse late and repeatedly. Current serum hormone markers are inaccurate in reflecting tumor burden in a subset of aGCT patients, indicating the need for a novel biomarker. We investigated the presence of circulating tumor DNA (ctDNA) harboring a FOXL2 or TERT promoter mutation in...

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Share to Biomarkers, Tumor
Share to Circulating Tumor DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein L2

Share to Granulosa Cell Tumor

Share to Neoplasm Recurrence, Local

Share to Ovarian Neoplasms

Share to Promoter Regions, Genetic

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Identifiers

PMID: 34083028
DOI: 10.1016/j.ygyno.2021.05.027

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