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Article

A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinoma.

Genome research - 1 Mar 2018

Lin Kuan-Ting, Ma Wai Kit, Scharner Juergen, Liu Yun-Ru, Krainer Adrian R

Abstract excerpt

Pre-mRNA splicing can contribute to the switch of cell identity that occurs in carcinogenesis. Here, we analyze a large collection of RNA-seq data sets and report that splicing changes in hepatocyte-specific enzymes, such as AFMID and KHK, are associated with HCC patients' survival and relapse. The switch of AFMID isoforms is an early event in HCC development and is associated with driver mutations in TP53 and...

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Source

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Identifiers

PMID: 29449409
DOI: 10.1101/gr.227181.117
PMCID: PMC5848607

Genes

AFMID
KHK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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