Article

A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinoma

2017-07-26

Abstract excerpt

Pre-mRNA splicing can contribute to the switch of cell identity that occurs in carcinogenesis. Here we analyze a large collection of RNA-Seq datasets and report that splicing changes in hepatocyte-specific enzymes, such as AFMID and KHK , are associated with HCC patients’ survival and relapse. The switch of AFMID isoforms is an early event in HCC development, and is associated with driver mutations in TP53 and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 270cf606-b6b2-57ed-a743-1b5eb649f05b
DOI: 10.1101/169029

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 10 closest

A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinomaDOI 10.1101/169029Read

A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinoma.Semantic proximity Read

Detection of recurrent alternative splicing switches in tumor samples reveals novel signatures of cancer.Semantic proximity Read

Liver cancer-specific mutations in functional domains of ADAR2 lead to the elevation of coding and non-coding RNA editing in multiple tumor-related genes.Semantic proximity Read

PhOxi-seq detects enzyme-dependent m 2 G in multiple RNA typesSemantic proximity Read

Antisense lncRNA transcription promotes A-to-I RNA editing via intermolecular dsRNA in breast cancerSemantic proximity Read

Recurrent alternative splicing isoform switches in tumor samples provide novel signatures of cancerSemantic proximity Read

De novo annotation of lncRNA HOTAIR transcripts by long-read RNA capture-seq reveals a differentiation-driven isoform switchSemantic proximity Read

Human Elp3/Kat9 is a mitochondrial tRNA modifying enzymeSemantic proximity Read

Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functionsSemantic proximity Read

A human-specific switch of alternatively spliced <i>AFMID</i> isoforms contributes to <i>TP53</i> mutations and tumor recurrence in hepatocellular carcinoma

Abstract excerpt

Topics

Identifiers and source

Related research