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N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours

15 Sept 2020

Abstract excerpt

N-terminal acetylation (Nt-Ac) is an abundant eukaryotic protein modification, deposited in humans by one of seven N-terminal acetyltransferase (NAT) complexes composed of a catalytic and potentially auxiliary subunits. The involvement of NATs in cancers is being increasingly recognised, but a systematic cross-tumour assessment is currently lacking. To address this limitation, we conducted here a multi-omic data...

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PMID: 32942614
DOI: 10.3390/cancers12092631

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