Article
Joint ancestry and association test indicate two distinct pathogenic pathways involved in classical dengue fever and dengue shock syndrome.
PLoS neglected tropical diseases - 1 Feb 2018
Oliveira Marisa, Lert-Itthiporn Worachart, Cavadas Bruno, Fernandes Verónica, Chuansumrit Ampaiwan, Anunciação Orlando, Casademont Isabelle, Koeth Fanny, Penova Marina, Tangnararatchakit Kanchana, Khor Chiea Chuen, Paul Richard, Malasit Prida, Matsuda Fumihiko, Simon-Lorière Etienne, Suriyaphol Prapat, Pereira Luisa, Sakuntabhai Anavaj
Abstract excerpt
Ethnic diversity has been long considered as one of the factors explaining why the severe forms of dengue are more prevalent in Southeast Asia than anywhere else. Here we take advantage of the admixed profile of Southeast Asians to perform coupled association-admixture analyses in Thai cohorts. For dengue shock syndrome (DSS), the significant haplotypes are located in genes coding for phospholipase C members...
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