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Article

In silico transcriptional regulation and functional analysis of dengue shock syndrome associated SNPs in PLCE1 and MICB genes.

Functional & integrative genomics - 1 May 2016

Taqi Malik Mumtaz, Waseem Durdana, Ismatullah Humaira, Haider Syed Aleem, Faisal Muhammad

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in PLCE1 and MICB genes increase risk for the development of dengue shock syndrome (DSS). We used Bioinformatics tools to predict alterations at the transcriptional and posttranslational levels driven by PLCE1 and MICB SNPs associated with DSS. Functional and phenotypic analysis conducted to determine deleterious SNPs and impact of amino acid substitution on the structure...

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Source

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Identifiers

PMID: 27038471
DOI: 10.1007/s10142-016-0489-9
PMCID: PMC4850189

Genes

MICB
PLCE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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