Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.

doi:10.1038/ng.960

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Article

Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.

Nature genetics - 16 Oct 2011

Khor Chiea Chuen, Chau Tran Nguyen Bich, Pang Junxiong, Davila Sonia, Long Hoang Truong, Ong Rick T H, Dunstan Sarah J, Wills Bridget, Farrar Jeremy, Van Tram Ta, Gan Tran Thi, Binh Nguyen Thi Nguyet, Tri Le Trung, Lien Le Bich, Tuan Nguyen Minh, Tham Nguyen Thi Hong, Lanh Mai Ngoc, Nguyet Nguyen Minh, Hieu Nguyen Trong, Van N Vinh Chau Nguyen, Thuy Tran Thi, Tan Dennis E K, Sakuntabhai Anavaj, Teo Yik-Ying, Hibberd Martin L, Simmons Cameron P

Abstract excerpt

Hypovolemic shock (dengue shock syndrome (DSS)) is the most common life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from Vietnam. Replication of the most significantly associated markers was carried out in an independent Vietnamese sample of 1,737 cases and 2,934 controls. SNPs at two loci showed genome-wide...

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Identifiers

PMID: 22001756
DOI: 10.1038/ng.960
PMCID: PMC3223402

Genes

MICB
PLCE1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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