Genetic risk for dengue hemorrhagic fever and dengue fever in multiple ancestries.

doi:10.1016/j.ebiom.2019.11.045

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Article

Genetic risk for dengue hemorrhagic fever and dengue fever in multiple ancestries.

EBioMedicine - 1 Jan 2020

Pare Guillaume, Neupane Binod, Eskandarian Sasha, Harris Eva, Halstead Scott, Gresh Lionel, Kuan Guillermina, Balmaseda Angel, Villar Luis, Rojas Elsa, Osorio Jorge E, Anh Dang Duc, De Silva Aruna Dharshan, Premawansa Sunil, Premawansa Gayani, Wijewickrama Ananda, Lorenzana Ivette, Parham Leda, Rodriguez Cynthia, Fernandez-Salas Ildefonso, Sanchez-Casas Rosa, Diaz-Gonzalez Esteban E, Saw Aye Khin, May Win Lai, Thein Min, Bucardo Filemon, Reyes Yaoska, Blandon Patricia, Hirayama Kenji, Weiss Lan, Singh Pardeep, Newton Jennifer, Loeb Mark

Abstract excerpt

BACKGROUND: Genetic risk factors for dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) and dengue fever (DF) are limited, in particular there are sparse data on genetic risk across diverse populations. METHODS: We conducted a genome-wide association study (GWAS) in a derivation and validation sample of 7, 460 participants of Latin American, South Asian, and South East Asian ancestries. We then developed a...

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Identifiers

PMID: 31901861
DOI: 10.1016/j.ebiom.2019.11.045
PMCID: PMC6940652

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