Article
Identification and ranking of recurrent neo-epitopes in cancer.
BMC medical genomics - 27 Nov 2019
Blanc Eric, Holtgrewe Manuel, Dhamodaran Arunraj, Messerschmidt Clemens, Willimsky Gerald, Blankenstein Thomas, Beule Dieter
Abstract excerpt
BACKGROUND: Immune escape is one of the hallmarks of cancer and several new treatment approaches attempt to modulate and restore the immune system's capability to target cancer cells. At the heart of the immune recognition process lies antigen presentation from somatic mutations. These neo-epitopes are emerging as attractive targets for cancer immunotherapy and new strategies for rapid identification of relevant...
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