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Article

A temperature-sensitive NUP116 null mutant forms a nuclear envelope seal over the yeast nuclear pore complex thereby blocking nucleocytoplasmic traffic.

The Journal of cell biology - 1 Oct 1993

Wente S R, Blobel G

Abstract excerpt

NUP116 encodes a 116-kD yeast nuclear pore complex (NPC) protein that is not essential but its deletion (nup116 delta) slows cell growth at 23 degrees C and is lethal at 37 degrees C (Wente, S. R., M. P. Rout, and G. Blobel. 1992. J. Cell Biol. 119:705-723). Electron microscopic analysis of nup116 delta cells shifted to growth at 37 degrees C revealed striking perturbations of the nuclear envelope: a double...

Topics

Animals
Cell Survival
Cytoplasm
Gene Deletion
In Situ Hybridization
Membrane Proteins
Microscopy, Electron
Mutation
Nuclear Envelope
Nuclear Pore Complex Proteins
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Temperature

Source

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Identifiers

PMID: 7691829
DOI: 10.1083/jcb.123.2.275
PMCID: PMC2119834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7691829-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A temperature-sensitive NUP116 null mutant forms a nuclear envelope seal over the yeast nuclear pore complex thereby blocking nucleocytoplasmic traffic.PMID 7691829Read ↗

The GLFG repetitive region of the nucleoporin Nup116p interacts with Kap95p, an essential yeast nuclear import factor.Semantic proximity Read ↗

Assembly and preferential localization of Nup116p on the cytoplasmic face of the nuclear pore complex by interaction with Nup82p.Semantic proximity Read ↗

The integral membrane protein snl1p is genetically linked to yeast nuclear pore complex function.Semantic proximity Read ↗

The yeast nucleoporin Nup188p interacts genetically and physically with the core structures of the nuclear pore complex.Semantic proximity Read ↗

Yeast nuclear pore complexes have a cytoplasmic ring and internal filaments.Semantic proximity Read ↗

The conserved Nup107-160 complex is critical for nuclear pore complex assembly.Semantic proximity Read ↗

A dominant-negative form of POM121 binds chromatin and disrupts the two separate modes of nuclear pore assembly.Semantic proximity Read ↗

Nic96p is required for nuclear pore formation and functionally interacts with a novel nucleoporin, Nup188p.Semantic proximity Read ↗

Nuclear pore complex function in Saccharomyces cerevisiae is influenced by glycosylation of the transmembrane nucleoporin Pom152p.Semantic proximity Read ↗

nup1 mutants exhibit pleiotropic defects in nuclear pore complex function.Semantic proximity Read ↗

Npp106p, a Schizosaccharomyces pombe nucleoporin similar to Saccharomyces cerevisiae Nic96p, functionally interacts with Rae1p in mRNA export.Semantic proximity Read ↗

Topology and functional domains of the yeast pore membrane protein Pom152p.Semantic proximity Read ↗

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