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Article

A temperature-sensitive NUP116 null mutant forms a nuclear envelope seal over the yeast nuclear pore complex thereby blocking nucleocytoplasmic traffic.

The Journal of cell biology - 1 Oct 1993

Wente S R, Blobel G

Abstract excerpt

NUP116 encodes a 116-kD yeast nuclear pore complex (NPC) protein that is not essential but its deletion (nup116 delta) slows cell growth at 23 degrees C and is lethal at 37 degrees C (Wente, S. R., M. P. Rout, and G. Blobel. 1992. J. Cell Biol. 119:705-723). Electron microscopic analysis of nup116 delta cells shifted to growth at 37 degrees C revealed striking perturbations of the nuclear envelope: a double...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 7691829
DOI: 10.1083/jcb.123.2.275
PMCID: PMC2119834

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Research trail→

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A temperature-sensitive NUP116 null mutant forms a nuclear envelope seal over the yeast nuclear pore complex thereby blocking nucleocytoplasmic traffic.PMID 7691829Read ↗

The GLFG repetitive region of the nucleoporin Nup116p interacts with Kap95p, an essential yeast nuclear import factor.Semantic proximity Read ↗

Assembly and preferential localization of Nup116p on the cytoplasmic face of the nuclear pore complex by interaction with Nup82p.Semantic proximity Read ↗

The integral membrane protein snl1p is genetically linked to yeast nuclear pore complex function.Semantic proximity Read ↗

The yeast nucleoporin Nup188p interacts genetically and physically with the core structures of the nuclear pore complex.Semantic proximity Read ↗

Yeast nuclear pore complexes have a cytoplasmic ring and internal filaments.Semantic proximity Read ↗

The conserved Nup107-160 complex is critical for nuclear pore complex assembly.Semantic proximity Read ↗

A dominant-negative form of POM121 binds chromatin and disrupts the two separate modes of nuclear pore assembly.Semantic proximity Read ↗

Nic96p is required for nuclear pore formation and functionally interacts with a novel nucleoporin, Nup188p.Semantic proximity Read ↗

Nuclear pore complex function in Saccharomyces cerevisiae is influenced by glycosylation of the transmembrane nucleoporin Pom152p.Semantic proximity Read ↗

nup1 mutants exhibit pleiotropic defects in nuclear pore complex function.Semantic proximity Read ↗

Npp106p, a Schizosaccharomyces pombe nucleoporin similar to Saccharomyces cerevisiae Nic96p, functionally interacts with Rae1p in mRNA export.Semantic proximity Read ↗

Topology and functional domains of the yeast pore membrane protein Pom152p.Semantic proximity Read ↗

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