Article
Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes.
Molecular biology of the cell - 1 Aug 2007
Palancade Benoit, Liu Xianpeng, Garcia-Rubio Maria, Aguilera Andrès, Zhao Xiaolan, Doye Valérie
Abstract excerpt
Increasing evidences suggest that nuclear pore complexes (NPCs) control different aspects of nuclear metabolism, including transcription, nuclear organization, and DNA repair. We previously established that the Nup84 complex, a major NPC building block, is part of a genetic network involved in DNA repair. Here, we show that double-strand break (DSB) appearance is linked to a shared function of the Nup84 and the...
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