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Article

A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis.

Open biology - 1 Nov 2021

Zhang Wanlu, Khan Azqa, Vitale Jlenia, Neuner Annett, Rink Kerstin, Lüchtenborg Christian, Brügger Britta, Söllner Thomas H, Schiebel Elmar

Abstract excerpt

The integral membrane protein Apq12 is an important nuclear envelope (NE)/endoplasmic reticulum (ER) modulator that cooperates with the nuclear pore complex (NPC) biogenesis factors Brl1 and Brr6. How Apq12 executes these functions is unknown. Here, we identified a short amphipathic α-helix (AαH) in Apq12 that links the two transmembrane domains in the perinuclear space and has liposome-binding properties. Cells...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34814743
DOI: 10.1098/rsob.210250
PMCID: PMC8611336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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