Article
Interindividual Differences in the Expression of ATP-Binding Cassette and Solute Carrier Family Transporters in Human Skin: DNA Methylation Regulates Transcriptional Activity of the Human ABCC3 Gene.
Drug metabolism and disposition: the biological fate of chemicals - 1 May 2018
Takechi Tomoki, Hirota Takeshi, Sakai Tatsuya, Maeda Natsumi, Kobayashi Daisuke, Ieiri Ichiro
Abstract excerpt
The identification of drug transporters expressed in human skin and interindividual differences in gene expression is important for understanding the role of drug transporters in human skin. In the present study, we evaluated the expression of ATP-binding cassette (ABC) and solute carrier (SLC) transporters using human skin tissues. In skin samples, ABCC3 was expressed at the highest levels, followed by SLCO3A1,...
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