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Article

Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies.

The Journal of biological chemistry - 17 Mar 2006

Wood Thomas C, Salavagionne Oreste E, Mukherjee Baidehi, Wang Liewei, Klumpp Annette F, Thomae Bianca A, Eckloff Bruce W, Schaid Daniel J, Wieben Eric D, Weinshilboum Richard M

Abstract excerpt

Arsenic contaminates ground water worldwide. Methylation is an important reaction in the biotransformation of arsenic. We set out to study the pharmacogenetics of human arsenic methyltransferase (AS3MT, previously CYT19). After cloning the human AS3MT cDNA, we annotated the human gene and resequenced its 5'-flanking region, exons, and splice junctions using 60 DNA samples from African-American (AA) and 60 samples...

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PMID: 16407288
DOI: 10.1074/jbc.M512227200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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