Article
Increased Expression of Plasma-Induced ABCC1 mRNA in Cystic Fibrosis.
International journal of molecular sciences - 11 Aug 2017
Ideozu Justin E, Zhang Xi, Pan Amy, Ashrafi Zainub, Woods Katherine J, Hessner Martin J, Simpson Pippa, Levy Hara
Abstract excerpt
The ABCC1 gene is structurally and functionally related to the cystic fibrosis transmembrane conductance regulator gene (CFTR). Upregulation of ABCC1 is thought to improve lung function in patients with cystic fibrosis (CF); the mechanism underlying this effect is unknown. We analyzed the ABCC1 promoter single nucleotide polymorphism (SNP rs504348), plasma-induced ABCC1 mRNA expression levels, and ABCC1...
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