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Article

Effect of Genetic Polymorphisms of Human SLC22A3 in the 5'-flanking Region on OCT3 Expression and Sebum Levels in Human Skin.

Journal of dermatological science - 1 Jan 2021

Takechi Tomoki, Hirota Takeshi, Fujii Kazushi, Nakahara Takeshi, Sakai Tatsuya, Maeda Natsumi, Furue Masutaka, Ieiri Ichiro

Abstract excerpt

BACKGROUND: Human organic cation transporter 3 (OCT3,SLC22A3) mediates the uptake of many important endogenous substances and basic drugs, and has been identified as one of the transporters that are highly expressed in human skin. However, the mechanisms responsible for variability in mRNA expression, and the role of SLC22A3 in human skin is not clear. OBJECTIVE: We examined the effects of the single nucleotide...

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PMID: 33168399
DOI: 10.1016/j.jdermsci.2020.10.010

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