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14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts

7 Feb 2018

Abstract excerpt

In humans, fetal erythropoiesis takes place in the liver whereas adult erythropoiesis occurs in the bone marrow. Fetal and adult erythroid cells are not only produced at different sites, but are also distinguished by their respective transcriptional program. In particular, whereas fetal erythroid cells express γ-globin chains to produce fetal hemoglobin (HbF), adult cells express β-globin chains to generate adult...

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PMID: 29432581
DOI: 10.1093/hmg/ddy051

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