Article
IGF2BP1 overexpression causes fetal-like hemoglobin expression patterns in cultured human adult erythroblasts.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2017
de Vasconcellos Jaira F, Tumburu Laxminath, Byrnes Colleen, Lee Y Terry, Xu Pauline C, Li May, Rabel Antoinette, Clarke Benjamin A, Guydosh Nicholas R, Proia Richard L, Miller Jeffery L
Abstract excerpt
Here we investigated in primary human erythroid tissues a downstream element of the heterochronic let-7 miRNA pathway, the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), for its potential to affect the hemoglobin profiles in human erythroblasts. Comparison of adult bone marrow to fetal liver lysates demonstrated developmental silencing in IGF2BP1. Erythroid-specific overexpression of IGF2BP1...
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