Article

Blood Relatives: Splicing Mechanisms underlying Erythropoiesis in Health and Disease

2018-08-30

Abstract excerpt

During erythropoiesis, hematopoietic stem and progenitor cells transition to erythroblasts en route to terminal differentiation into enucleated red blood cells. Transcriptome-wide changes underlie distinct morphological and functional characteristics at each cell division during this process. Many studies of gene expression have historically been carried out in erythroblasts, and the biogenesis of β-globin mRNA—th...

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Literature Corpus work: c0b8c8f0-c9a5-5664-9634-9016580e41b5
DOI: 10.12688/f1000research.15442.1

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