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Article

Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors

19 Jan 2015

Abstract excerpt

BACKGROUND: DNA methylation is an epigenetic modification that plays an important role during mammalian development. Around birth in humans, the main site of red blood cell production moves from the fetal liver to the bone marrow. DNA methylation changes at the β-globin locus and a switch from fetal to adult hemoglobin production characterize this transition. Understanding this globin switch may improve the...

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Share to Epigenetics and DNA Methylation
Share to Erythrocyte Function and Pathophysiology
Share to Hemoglobinopathies and Related Disorders

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PMID: 25606059
DOI: 10.1186/s13073-014-0122-2

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