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Article

let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching

16 Feb 2024

Abstract excerpt

ABSTRACT: The switch from fetal hemoglobin (γ-globin, HBG) to adult hemoglobin (β-globin, HBB) gene transcription in erythroid cells serves as a paradigm for a complex and clinically relevant developmental gene regulatory program. We previously identified HIC2 as a regulator of the switch by inhibiting the transcription of BCL11A, a key repressor of HBG production. HIC2 is highly expressed in fetal cells, but the...

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Share to Erythrocyte Function and Pathophysiology
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PMID: 38364109
DOI: 10.1182/blood.2023023399

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