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Article

LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo.

Blood - 8 Aug 2013

Lee Y Terry, de Vasconcellos Jaira F, Yuan Joan, Byrnes Colleen, Noh Seung-Jae, Meier Emily R, Kim Ki Soon, Rabel Antoinette, Kaushal Megha, Muljo Stefan A, Miller Jeffery L

Abstract excerpt

Reactivation of fetal hemoglobin (HbF) holds therapeutic potential for sickle cell disease and β-thalassemias. In human erythroid cells and hematopoietic organs, LIN28B and its targeted let-7 microRNA family, demonstrate regulated expression during the fetal-to-adult developmental transition. To explore the effects of LIN28B in human erythroid cell development, lentiviral transduction was used to knockdown LIN28B...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23798711
DOI: 10.1182/blood-2012-12-472308
PMCID: PMC3739030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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