Article
Defective XRN3-mediated transcription termination in Arabidopsis affects the expression of protein-coding genes.
The Plant journal : for cell and molecular biology - 1 Mar 2018
Krzyszton Michal, Zakrzewska-Placzek Monika, Kwasnik Aleksandra, Dojer Norbert, Karlowski Wojciech, Kufel Joanna
Abstract excerpt
Arabidopsis thaliana contains two nuclear XRN2/3 5'-3' exonucleases that are homologs of yeast and human Rat1/Xrn2 proteins involved in the processing and degradation of several classes of nuclear RNAs and in transcription termination of RNA polymerase II. Using strand-specific short read sequencing we show that knockdown of XRN3 leads to an altered expression of hundreds of genes and the accumulation of uncapped...
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