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Article

Uncommon Filaggrin Variants Are Associated with Persistent Atopic Dermatitis in African Americans.

The Journal of investigative dermatology - 1 Jul 2018

Margolis David J, Mitra Nandita, Gochnauer Heather, Wubbenhorst Bradley, D'Andrea Kurt, Kraya Adam, Hoffstad Ole, Gupta Jayanta, Kim Brian, Yan Albert, Fuxench Zelma Chiesa, Nathanson Katherine L

Abstract excerpt

Atopic dermatitis (AD) is a common illness that has been associated with filaggrin gene (FLG) loss of function (LoF) variation. In African Americans, a group that commonly has AD and has not been well studied, FLG LoF variation is rarely found. Our objective was to use massively parallel sequencing to evaluate FLG LoF variation in children of African ancestry to evaluate the association between FLG LoF variation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29428354
DOI: 10.1016/j.jid.2018.01.029
PMCID: PMC6272058

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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