Article
Prevalence of filaggrin loss-of-function variants in Chilean population with and without atopic dermatitis.
International journal of dermatology - 1 Mar 2022
Cárdenas Geovanna V, Iturriaga Carolina, Hernández Caroll D, Tejos-Bravo Macarena, Pérez-Mateluna Guillermo, Cabalin Carolina, Urzúa Marcela, Venegas-Salas Luis F, Fraga Juan P, Rebolledo Boris, Poli Maria C, Repetto Gabriela M, Casanello Paola, Castro-Rodríguez José A, Borzutzky Arturo
Abstract excerpt
BACKGROUND: Filaggrin (FLG) loss-of-function variants are major genetic risk factors for atopic dermatitis (AD), but these have not been studied in Latin American populations with and without AD. METHODS: FLG variants R501X and 2282del4 were genotyped in 275 Chilean adults with and without AD from the "Early origins of allergy and asthma" (ARIES) cohort and in 227 patients from an AD cohort based in Santiago,...
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