Article
Tiled array-based sequencing identifies enrichment of loss-of-function variants in the highly homologous filaggrin gene in African-American children with severe atopic dermatitis.
Experimental dermatology - 1 Sept 2018
Mathyer Mary Elizabeth, Quiggle Ashley M, Wong X F Colin C, Denil Simon L I J, Kumar Monique G, Ciliberto Heather M, Bayliss Susan J, Common John E, de Guzman Strong Cristina
Abstract excerpt
Filaggrin (FLG) loss-of-function (LOF) variants are a major risk factor for the common inflammatory skin disease, atopic dermatitis (AD) and are often population-specific. African-American (AA) children are disproportionately affected with AD, often later developing asthma and/or allergic rhinitis and comprise an atopy health disparity group for which the role of FLG LOF is not well known. Discovery of FLG LOF...
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