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Article

The persistence of atopic dermatitis and filaggrin (FLG) mutations in a US longitudinal cohort.

The Journal of allergy and clinical immunology - 1 Oct 2012

Margolis David J, Apter Andrea J, Gupta Jayanta, Hoffstad Ole, Papadopoulos Maryte, Campbell Linda E, Sandilands Aileen, McLean W H Irwin, Rebbeck Tim R, Mitra Nandita

Abstract excerpt

BACKGROUND: Atopic dermatitis (AD) is a common skin disease that is characterized by recurrent episodes of itching. Filaggrin (FLG) loss-of-function (FLG null) mutations have been associated with an increased risk of AD. OBJECTIVE: We sought to evaluate the effect of individual FLG null mutations on the persistence of AD over time. METHODS: We evaluated a multiyear prospective cohort study of children with AD...

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Source

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Identifiers

PMID: 22951058
DOI: 10.1016/j.jaci.2012.07.008
PMCID: PMC3462287

Genes

FLG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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