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Article

Uncommon variants in FLG2 and TCHHL1 are associated with remission of atopic dermatitis in a large longitudinal US cohort.

Archives of dermatological research - 1 Dec 2022

Berna Ronald, Mitra Nandita, Hoffstad Ole, Wubbenhorst Bradley, Nathanson Katherine L, Margolis David J

Abstract excerpt

Atopic dermatitis (AD) is a relapsing inflammatory skin disease; filaggrin (FLG) variation has been consistently associated with its pathogenesis. Filaggrin-2 (FLG2) and trichohyalin-like-1 (TCHHL1) are members of the same protein family (S100 fused-type proteins), are similar in structure to FLG, and may be involved in AD pathogenesis. We sought to evaluate the association between variation in FLG2, TCHHL1 and...

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Identifiers

PMID: 34984527
DOI: 10.1007/s00403-021-02319-7
PMCID: PMC9250940

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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