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Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants

19 Oct 2017

Abstract excerpt

The filaggrin gene (FLG) is essential for skin differentiation and epidermal barrier formation. FLG loss-of-function (LoF) variants are associated with ichthyosis vulgaris and the major genetic risk factor for developing atopic dermatitis (AD).1-3 Genetic stratification of patients with AD according to FLG LoF risk is a common practice for both research and clinical studies; however, few studies comprehensively...

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PMID: 29056476
DOI: 10.1016/j.jaci.2017.10.001

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