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Article

Pathway-induced allelic spectra of diseases in the presence of strong genetic effects.

Human genetics - 1 Mar 2018

Kanoungi George, Nothnagel Michael

Abstract excerpt

Complex diseases are frequently modeled as following an additive model that excludes both intra- and inter-locus interaction, while at the same time reports on non-additive biological structures are ample, prominently featuring numerous metabolic and signaling pathways. Using extensive forward population simulations, we explored the impact of three basic pathway motifs on the relationship between epidemiological...

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PMID: 29423653
DOI: 10.1007/s00439-018-1872-5

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