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Article

Use of pathway information in molecular epidemiology.

Human genomics - 1 Oct 2009

Thomas Duncan C, Conti David V, Baurley James, Nijhout Frederik, Reed Michael, Ulrich Cornelia M

Abstract excerpt

Candidate gene studies are generally motivated by some form of pathway reasoning in the selection of genes to be studied, but seldom has the logic of the approach been carried through to the analysis. Marginal effects of polymorphisms in the selected genes, and occasionally pairwise gene–gene or gene–environment interactions,are often presented, but a unified approach to modelling the entire pathway has been...

Topics

Bayes Theorem
Colorectal Neoplasms
Epistasis, Genetic
Folic Acid
Genetic Markers
Genome-Wide Association Study
Genotype
Humans
Metabolic Networks and Pathways
Molecular Epidemiology
Polymorphism, Genetic

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PMID: 21072972
DOI: 10.1186/1479-7364-4-1-21
PMCID: PMC2999471

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