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Article

Network Modeling of Crohn's Disease Incidence.

PloS one - 1 Jan 2016

Victor Jean-Marc, Debret Gaëlle, Lesne Annick, Pascoe Leigh, Carrivain Pascal, Wainrib Gilles, Hugot Jean-Pierre

Abstract excerpt

BACKGROUND: Numerous genetic and environmental risk factors play a role in human complex genetic disorders (CGD). However, their complex interplay remains to be modelled and explained in terms of disease mechanisms. METHODS AND FINDINGS: Crohn's Disease (CD) was modeled as a modular network of patho-physiological functions, each summarizing multiple gene-gene and gene-environment interactions. The disease...

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Identifiers

PMID: 27309539
DOI: 10.1371/journal.pone.0156138
PMCID: PMC4911211

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