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Article

An important role for the activation peptide domain in controlling factor IX levels in the blood of haemophilia B mice.

Thrombosis and haemostasis - 1 Dec 2005

Begbie Megan E, Mamdani Asif, Gataiance Sharon, Eltringham-Smith Louise J, Bhakta Varsha, Hortelano Gonzalo, Sheffield William P

Abstract excerpt

The factors responsible for the removal of injected factor IX (fIX) from the blood of individuals with haemophilia B are only partly understood, and may include binding to endothelial or subendothelial sites, passive extravasation related to size or charge, or interactions requiring fIX activation. To investigate these issues, we have produced and characterised recombinant fIX proteins with amino acid changes:...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16411385
DOI: 10.1160/TH04-03-0201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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