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Article

Identification of a protein S-binding site in the C2 domain of factor VIII light chain.

Research and practice in thrombosis and haemostasis - 1 Jul 2026

Furukawa Shoko, Takeyama Masahiro, Nogami Keiji

Abstract excerpt

Background: We demonstrated that protein S (PS) directly impairs the intrinsic tenase complex, independent of activated protein C (APC), by competitively inhibiting the binding of factor (F)IXa to the A2 domain (residues 488-490) and light chain (LCh) of FVIIIa. Objectives: This study investigated the PS-binding sites within the FVIII-LCh subunit. Methods: Binding interactions between PS and the FVIII-LCh were...

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Share to Enzyme-Linked Immunosorbent Assay
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42568798
DOI: 10.1016/j.rpth.2026.106831
PMCID: PMC13448017

Genes

APC
C2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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