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Article

Laminin G domains define a critical interface for protein S-mediated factor IXa inhibition.

Journal of thrombosis and haemostasis : JTH - 1 Apr 2026

Yasmin Rafika, Chattopadhyay Rima, Vandana, Kumar Narender, Dorsey Adrianne, Chatterjee Sabyasachi, Choudhury Sumita, Pilli Vijaya Satish, Temple Brenda, Majumder Rinku

Abstract excerpt

BACKGROUND: Hemostasis is maintained through a delicate balance between procoagulant and anticoagulant mechanisms. Protein S (PS), a multidomain, vitamin K-dependent glycoprotein, contributes to this balance not only as a cofactor for activated protein C and tissue factor pathway inhibitor but also by directly inhibiting activated factor IX (FIXa). However, the structural determinants underlying FIXa inhibition...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41506583
DOI: 10.1016/j.jtha.2025.11.035
PMCID: PMC13416700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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