Laminin G domains define a critical interface for protein S-mediated factor IXa inhibition.

Abstract excerpt

BACKGROUND: Hemostasis is maintained through a delicate balance between procoagulant and anticoagulant mechanisms. Protein S (PS), a multidomain, vitamin K-dependent glycoprotein, contributes to this balance not only as a cofactor for activated protein C and tissue factor pathway inhibitor but also by directly inhibiting activated factor IX (FIXa). However, the structural determinants underlying FIXa inhibition...

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• Binding Sites
• Blood Coagulation
• Laminin
• Molecular Docking Simulation
• Mutagenesis, Site-Directed