Article
Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B
2019-03-25
Abstract excerpt
<h4>ABSTRACT</h4> The immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptor G6b-B is critical for platelet production and activation, loss of which results in severe macrothrombocytopenia and aberrant platelet function in mice and humans. Using a combination of immunohistochemistry, affinity chromatography and proteomics, we identified the extracellular matrix heparan sulfate (HS) proteoglycan...
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Identifiers and source
- Literature Corpus work
- 6f54814d-933a-57f1-8ad6-0996423b3736
- DOI
- 10.1101/584698