Article
Factor XIII activity mediates red blood cell retention in venous thrombi.
The Journal of clinical investigation - 1 Aug 2014
Aleman Maria M, Byrnes James R, Wang Jian-Guo, Tran Reginald, Lam Wilbur A, Di Paola Jorge, Mackman Nigel, Degen Jay L, Flick Matthew J, Wolberg Alisa S
Abstract excerpt
Venous thrombi, fibrin- and rbc-rich clots triggered by inflammation and blood stasis, underlie devastating, and sometimes fatal, occlusive events. During intravascular fibrin deposition, rbc are thought to become passively trapped in thrombi and therefore have not been considered a modifiable thrombus component. In the present study, we determined that activity of the transglutaminase factor XIII (FXIII) is...
Topics
- Animals
- Blood Coagulation
- Disease Models, Animal
- Erythrocytes
- Factor XIII
- Factor XIII Deficiency
- Factor XIIIa
- Fibrinogen
- Homozygote
- Humans
- Male