Article
Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer.
PloS one - 1 Jan 2018
Catalano Calogerina, da Silva Filho Miguel Inacio, Frank Christoph, Jiraskova Katerina, Vymetalkova Veronika, Levy Miroslav, Liska Vaclav, Vycital Ondrej, Naccarati Alessio, Vodickova Ludmila, Hemminki Kari, Vodicka Pavel, Weber Alexander N R, Försti Asta
Abstract excerpt
Constitutive activation of interferon signaling pathways has been reported in colorectal cancer (CRC), leading to a strong CD8+ T cell response through stimulation of NLRC5 expression. Primed CD8+ T cell expansion, however, may be negatively regulated by PD-L1 expression. Additionally, aberrant PD-L1 expression enables cancer cells to escape the immune attack. Our study aimed to select potential regulatory...
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